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These findings may reflect higher rates ofenteric skin colonization and wound contamination in patients with fecal and urinaryincontinence, limited soft tissue availability for wound coverage, or lack of sensationthat may predispose to peri-incisional pressure ulceration of skin [21, 22].

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The liver conjugates bilirubin, anormal breakdown product of the heme from red bloodcells, and secretes the glucuronide conjugate into thebile. Bowman AL et al (2007) Small molecule inhibitors of the MDM2-p53 interaction discoveredby ensemble-based receptor models.

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